OgyStab
 Ogryn Build - Warhammer 40k: Darktide 

Ogryn Stab - and then Stab AND STAB. when all ogryn has is a pointy fix everything by stabby.

Cleaver - pick your favorite mark, all work well. IV is best single target, but mostly we can use the ripper for that so any work. Club MK III also works almost identically to the cleavers for this build.

Perks:

• Flak - great for stabbing elites and difficult to kill enemies
• Maniac - for better Mutant stab, and the occassional special that gets too close

Blessings:

• Slaughterer - best stabby blessing 100% ogryn approved- only decent power/damage blessing available.
• Savage - Ogryn has a bunch of toughness regen you can get for nearly free - so more stabby. Confident Strike is a VERY strong Toughness regen blessing and can be worth taking if you really want that extra tankiness.

Ripper V or II - V is the most accurate hip shooting, best for killing specials, II is more oomph for dakka bosses and hordes of elites. Pretty much any gun will work on this build.

Perks: 

• Carapace - one stab into 2 bursts will kill crushers with this. Can be Flak or Unyielding (particularly on Monster Maelstrom)
• Maniac - For special killing power, lets us one tap trappers at medium ranges, helps to kill Flamers and mutants at range as well.

Blessing:

• Can Opener - one thing we lack is Carapace damage, and is one of the primary reasons to take this over other weapons. Weapon special applies bleed and regenerates toughness from Smash 'Em
• Blaze Away - Most consistent damage blessing on Rippers as you don't have to kill anything, and they get very little damage from criticals.

Smash'em notable as during hordes the cleaver will just rip through enemies passively regenning all your toughness - so vs bosses and elites your heavy can regen toughness otherwise lights should be spammed on cleaver.

Batter lets us do significant boss damage, as well as two stab Crushers with the Ripper when combined with Dominate. 

Indomitable will regenerate toughness in a pinch, and will bleed all enemies giving a boost to resistance for a period. We go Feel No Pain as we won't be using many heavy attacks so it is the only option that makes much sense. 

Toughness Replenishment  appears to be exactly the same as Toughness Regeneration (why have two things that appear to be identical? I dunno.) and only impact regen from Cohesion. They are all additive multipliers off the base 7.5~ toughness regen per second, so this build will have 20~ toughness regen as long as you are not within 4m of an enemy which can be significant regenerating after getting hit by gunners or flame. Can easily be replaced with Sniper/Gunner resist and talents elsewhere.

Towering Presence is a great option, can be replaced by Trample (Or replace the flat 15 toughness for Trample)

Payback Time and Bruiser Are both great options, I would recommend trying both talents

It is always best to proc Dominate before using Frag Bomb is the best option

HUGE
Currently Ogryn has a base of 36% (20% TDR and 20% health resist, which stacks with itself for damage taken to toughness) All the toughness reduction nodes stack additively (30% TDR), and also stacks additively with Feels no Pain for 55% TDR. Together being a passive 71.2% TDR which is crazy.